What do you say to someone reduced to a wheelchair and unable to speak due to ALS, Lou Gehrig's disease?

As gut wrenching as it may seem to you it is even harder for the patient.  Be yourself.  Talk with her as if you were best buds.  Do not change your visitation routein because she is ill.  Even sick people want friends who visit.  Don't be afraid to discuss the usual things.  She probably would like very much to still feel she is a part of  LIFE.  It may be very akward at first, but if you do not try to be someone you are not and just be yourself it will go smoothly.  Afterward you will be glad you did and so will she. 

To have someone read an email is not the same at all.  It sends a message that  you are uncomfortable in her presence and don't want to see her because of her illness.  Forget that idea!   --- Citrine1

I would call and ask if she wants company. If she does, when you first see her.; tell her you know she can only blink her eyes.You can ask her questions. (2 blinks is yes, 1 is no) Maybe she would enjoy having you tell her whats going on with your family and other things she might want to know. Be yourself. Maybe she would like you to read a book to her; maybe you can watch a dvd together. Use your imagination. She is STILL your friend!What did you do before she couldnt talk?Good Luck.

If the person can only use her eyes, she musn't have much energy at all and I would think she would be very tired from having company. However, you might want to send an e mail and ask her if she'd like company. If she does, just sit and read to her.  play some music for her, or chat about every day things. Show her an album of pictures if she's a close friend.  I think a lot of people communicate by closing their eyes once for "yes", or closing their eyes twice for "no".  What a cruel disease!