Hunter Medical Research Institute (HMRI) researchers at the University of Newcastle are working on a reversible male contraceptive as part of their studies into male infertility. Dr Mark Baker from the University’s Faculty of Science and Information Technology has identified key enzymes including certain kinases that are believed to play a major role in male infertility.
The discovery has led researchers toward the development of a reversible male contraceptive, which would work by inhibiting the key enzymes in sperm, thereby causing infertility. Removal of the drug would allow the function of the kinase to resume as per normal, allowing a reversible, safe method of contraception.
The work uses two dimensional gel technology DIGE (2-D Fluorescence Difference Gel Electrophoresis) developed by partner GE Healthcare which allows the researchers to quickly compare the difference in protein profiles of multiple normal and infertile sperm samples.
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