It really depends on your medical condition and why you are taking those Meds to begin with.
Most people don't, and keep on taking them. You might be able to with a big adjustment to your life style, like changing your diet, doing sports and using natural food supplements, but only a DR. who knows your medical history and saw your blood tests results can really give you a specific answer.
Whatever you do - don't just stop the medications without talking to a DR. before, this might be dangerous.