Cane toads are dangerous to any animal that tries to eat it, including dogs, and they can even be dangerous to humans. The have poisonous glands and can sqirt venom at an enemy as well.
Many species prey on the Cane Toad in its native distribution. These include the Broad-snouted Caiman (Caiman latirostris), the Banded Cat-eyed Snake (Leptodeira annulata), the eel (family: Anguillidae), various species of killifish, the Jungle Perch (Kuhila rubestris), some species of catfish (order: Siluriformes) and some species of ibis (subfamily: Threskiornithinae). Predators outside the Cane Toad's native range include the Whistling Kite (Haliastur sphenurus), the Water Rat (Hydromys chrysogaster), the Black Rat (Rattus rattus) and the Water Monitor (Varanus salvator). Occasional cases of the Tawny Frogmouth (Podargus strigoides) and the Papuan Frogmouth (Podargus papuensis)[10] feeding on Cane Toads have been reported. These predators possess either a tolerance to the Cane Toad's toxins or behavioural adaptations that allow them to avoid the most poisonous areas of the frog as they hunt and consume it.