I have been on 100 MG of Zoloft for going on 8 years. It was an excellent antidote to severe anxiety and beginning serious depression, after dealing with continuous extreme crisis' with my daughter over a 15 year period. During this time I have gained 30 lbs mostly in the ab area. I have seen and read the many reports that say SSRI's cause weight gain, inflammation, organ inefficiency and on and on. I have tried to taper just 25 mg every other day several times only to start to experience physical anxiety and oversensitivity within a week. I have heard Wellbutrin is less likely to add weight or inhibit sex, but not good for anxiety. I also read about alleged programs that work by substituting fish oil, CLA and vit E. I am going back to following WW and I do exercise almost daily.....fast walking or spinning. ( I did used to overexercise until I had a leaky heart valve so had to become more moderate.....also caused weight gain.) Do you believe it is possible to lose while still on Zoloft? To a degree I think the beliefs about this may be partly that many women are menopausal when starting these meds, and feel more relaxed and less disciplined. Or maybe I am wrong and it really is what is making me fat.(ter). Please give me informed ideas. Thank you.