He needs to consolidate his debts as a business and have that business declare bankruptcy, not himself personally.
As for bankruptcy, I'm not sure if that would jeopardize his license...but let's walk through this. If he and you do nothing, you will lose everything plus more (making payments with money you can't afford to lose), and be forced to declare bankruptcy with nothing to show for it, and he loses his license and your relationship might be affected by all of this. If you plan this out now, get a good legal advisor familiar with this stuff(not an accountant)...you have the potential to save some of your assets and possessions, and may still lose his license.
You guys might want to cut your losses, and stop throwing good money after bad.