Shulman's syndrome Eosinophilic fasciitis: A disease which leads to inflammation and thickening of the skin and fascia. (The fascia is a lining tissue under the skin that covers a surface of underlying tissues. When the fascia is inflamed, the condition is referred to as "fasciitis.") In eosinophilic fasciitis, the involved fascia is inflamed with the eosinophil white blood cells. There is progressive thickening, and often redness and warmth, and hardness of the skin surface.
