The answer depends on where you're coming from. If you're coming from Tel Aviv or Jerusalem, use Road 1, and exit at Latrun junction.
If you're coming from farther away, I recommend using Road 6, until Daniel junction, and then on Road 1 (direction of Jerusalem), and exit from Road 1 at Latrun junction.
From Latrun Junction, take road 3 southbound and after a few km you'll see signs to Neve Shalom.