It really depends on the type of girl you're trying to pick up.  I worked in a convenience store in my 20's, and got 'hit on' constently, in every way you can imagine.  Then one day this carpenter guy came in, he got some gas and bought a sandwich, and started to eat it right there in the store.. I said to him "your hands are dirty, don't you want to wash them before you eat?"  And this wonderful guy captured my heart immediately,  when he said; "don't you know that Jesus ate with dirty hands?" 

Not only do I still love him 21 years later, but I will never forget the first thing he said to capture my attention.