Eunice Kennedy Shriver was a lot like her brother, President Kennedy.  What people don't know is that she had Addison's Disease too, like her brother.  See how long she lived.  (President Kennedy's worst problem was probably his back pain.)  Eunice developed the Special Olympics for mentally-challenged children.  It was always claimed she did so in honor of her sister Rose Mary. 

Eunice's father, Joe Kennedy, let a doctor perform a lobotomy on Rose Mary.  She spent the rest of her life in an institution.  Basically, she was a little slow, but Joe wanted to tame her promiscuity.

It's my belief that Maria Shriver suffers from Addison's Disease too.