That's an interesting question....
2100 AD - Global warming. (I think)
We're a plague and the only thing that will stop us is us. (Our own greed, consumption and waste, which are topics that are not that unrelated.)
Just ignore this answer and move on to the next. I'm so paranoid, I'm thankful to every living day. I have no idea how or when, but something tells me that it'll have something to do with greed.