For sure our brain is not designed to understand all - we can only think and experience in 3 dimensions and for us every cause has an effect. In quantum physics we know that things can happen without a cause - it is only brain that believes everything should have a cause.
Regarding the reference to God, I believe already for ages our brain has a way to solve to unknown - assign it to a God. In the ancient Greek time thunder and lighting were Gods, now we know better and we have less Gods to assign.
A good book to understand a little beyond our imagination is called flatland
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Enjoy